D.A.V.E. stands for Digitally Advanced Villain Emulator and was inspired by the insane computer, HAL 9000, in 2001: A Space Odyssey.
Richard Green took over voicing Professor Hugo Strange after Frank Gorshin's death in May 2005.
The super villains shown on D.A.V.E.'s screen are: Mr. Freeze, The Riddler, The Joker, The Penguin, and Clayface.
At one point, Professor Strange says, "the Dark Knight returns", an obvious reference to the graphic novel, The Dark Knight Returns, by Frank Miller, as well as the 2nd film in the Christopher Nolan Batman trilogy.