- Gilligan moves to the other side of the island when the other castaways suddenly become allergic to him.
- The Skipper (Alan Hale Jr) comes down with a sneezing and itching fit that the Professor (Russell Johnson) tries to diagnose as a tropical disease, but he soon notices it only seems to occur near Gilligan (Bob Denver). He tells the Skipper that he is suffering from "communitus allergitatus," a common allergy, and tries to find out if something on Gilligan is causing the allergy. Not finding anything, he then tries to test if it could by psychosomatic or unconscious by testing the Skipper and his proximity to the other Castaways but this fails. Gilligan has no choice but to move out of the Boy's Hut and stay in the Supply Hut with the Professor, who soon has sneezing and itching fits himself, then with The Howells (Jim Backus and Natalie Schafer) who also have the same allergy and finally with Ginger (Tina Louise) and Mary Ann (Dawn Wells) who also sneeze. Eventually, everyone turns out to be allergic to Gilligan who leaves camp for a cave on the other side of the island. Initial attempts to bring him back are unsuccessful due to allergic reactions kicking in. The Professor eventually manages to create a vaccine to treat the allergies, but no one is willing to take it thanks to the huge needle that was built to inject the serum. Unable to live without his little buddy, the Skipper finally decides to take the anti-allergy shot the Professor created but faints when he sees the needle. At first, everything seems to be going all right as the Castaways watch Gilligan and the Skipper play checkers together, and everyone decides to get the shots required to keep Gilligan around. Unfortunately, the predicament ends up making everyone miserable and short-tempered due to the needle causing their arms to ache. By now, however, Gilligan has learned the real source of the allergy as the papaya nut oil he was using as hair tonic. Unfortunately, by now, the others get so angry that they went through all of the discomfort for nothing that they end up chasing Gilligan into the jungle. The following day after tempers have dwindled, the Skipper and the Professor both prepare for some retaliation against Gilligan as a practical joke. When he comes by his hut, the Professor tells Gilligan that he feels that he needs an anti-allergy shot in case the papaya oil has entered his bloodstream, but it's really a pretense to scare Gilligan with a monstrous bamboo needle for punishment. Gilligan is willing to take the shot since the others endured so much discomfort, but he balks at the size of the needle, backing up into the real needle by accident.
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