Goofs

Throughout the whole film the hostess's skirts were short, but during one scene after the outbreak, one of their skirts are knee length.

When First Officer Ray comes out of the cargo hold, the amount of blood on his shirt keeps changing between shots.

Almost every time someone has blood on their clothes, the amount changes from scene to scene. Besides the co-pilot, the most noticeable one is Cara, the girl who throws up in the bathroom. When she comes in she has a tiny amount of blood on her forehead, but after throwing up, she has a large amount of blood on her face. The guy sitting next to her has splashes on his jacket; right afterward, he has much more.

A flight traveling between LA and Paris would cross North America first. If the flight ended up near Yellowknife over the ocean, the pilot would have had start going in the wrong direction for this course misdirection to occur.

During the discussion at the Pentagon, there is talk of a new strain of "malaria virus." Malaria is caused by Plasmodium, a protozoan parasite, not a virus.

The pilot descends to find calmer air. In thunderstorms, lower altitudes tend to be more turbulent and higher altitudes more calm.

The fighter plane that is dispatched to shoot down the airplane is an F-14 Tomcat. It was retired from the U.S. Navy fleet on 22 September 2006, having been replaced by the F/A-18E/F Super Hornet. As of 2007, it remains in service only with the Islamic Republic of Iran Air Force.

When the Pentagon is shown, the captioning says that it is in Washington, DC, but the Pentagon's technical location is in Arlington, Virginia. However, it has been insisted that the building is not just close physically, but is very linked to Washington's political and economic culture, that the employees generally think of themselves more as 'Washingtonian' than 'Virginian'.

Kristen Kerr's character, Meagan, has a name tag on and in close ups viewers can clearly see it is spelled MEAGAN (see the image added). Although, in the credits it is listed as being spelled MEGAN.