Both the series finale and pilot fade out to Citizen King's "Better Days".
When Francis drops his employee card, on the card it clearly reads "FRANCIS NOLASTNAME."
We never find out where in the USA Malcolm's family lives. However, in Stevie in Hospital Hal and Jamie sit on a park bench with ironwork by Kings River Casting from Sanger, Ca. Sanger is 3,000 miles from Harvard
With this episode, Craig Lamar Traylor (Stevie Kenarban) is the only cast member outside of Malcolm and his family to appear in the Pilot and the final episode.
In the pilot there is a shot of Malcolm sitting alone at lunch with the other kids at school keeping a 6 foot radius distance from him. This shot is referenced twice during Malcolm's valedictorian speech.
Linwood Boomer: The creator of the series, playing the role of the loan shark that Hal tries to get money from.