Plot

Meg turns to killing John's friends in order to get the Colt. Sam and Dean stakeout the Demon's next target; a family with a six month old baby showing signs of special abilities. John heads off alone to confront Meg.

Now Dean and Sam are finally reunited with their father John Winchester, he explains to be on the trace of a powerful demon which attacks people with young children, causing fatal fires, as happened to their mother Mary and to Jessica; he also learned to read predictive signs, and they point to Salvation, Iowa, so they go there, looking for catalytic kids. Then they learn a priest has been murdered and another friend, Caleb, has his throat slid while dad is on the phone with Meg or whatever possesses her, demanded he travels to Lincoln to deliver the old demon-killing Colt or everyone they ever cared for or were helped by will die too. To the boys' horror dad accepts, but explains to them he'll bring an ordinary antique instead, to win time while they stay behind and kill the demon when he attacks the innocent family, but split up they'll all be in grave danger...—KGF Vissers

After killing two close friends of John Winchester, Meg calls him and proposes to exchange the colt manufactured in 1835 by Samuel Colt per the lives of his other friends. John travels to meet her with a fake revolver, while Dean and Sam stay to protect a family threatened by the demon that killed Mary and Jessica. John is trapped by Meg and a demon in human shape while his sons battle against the evil fiend.—Claudio Carvalho, Rio de Janeiro, Brazil

In Blue Earth, Minnesota, a priest is reading the Bible at his altar when Meg enters, ostensibly seeking solace. The priest encourages her, as "Salvation is there for all who seek it." When she reveals her black eyes, the priest retreats in horror to an underground office fitted out with the tools of a Hunter, with research and runes spanning the walls. Meg follows him, kicking in the barred doors. He asks, "What do you want?" and she demands the location of John Winchester, who he refuses to betray. She slits his throat.

Back in Manning, Colorado, John is sharing his research of the last 20 years with Sam and Dean. He explains the trail he has followed and the telltale signs. Sam's guilt at being the cause of the deaths of both Mary and Jess turns into anger and pain. But neither John nor Dean allow him to wallow. John sees the signs starting again in Salvation, Iowa, and is intent on saving another family from the pain and loss suffered by the Winchesters.

On the road, John receives the news that Pastor Jim Murphy, the priest from the opening, has been murdered, probably by demons. John feels the pressure to hurry, to find the next family on the demon's list. In despair, John mourns his friend and states "This ends... now... I'm ending it. I don't care what it takes."

Overcome by the size of their task, they split up to cover more territory and research all infants turning 6 months old in the coming week. As Sam leaves the medical center where he has been reviewing birth records, he has a vision of the demon's next target. Following the signs in his vision, he meets the young mother Monica and her daughter, Rosie. Unable to warn her, he returns to Dean and John. John is angry that the boys hadn't told him before about Sam's visions. Dean points out John's unresponsiveness and angrily states he would have had better luck winning the lottery than reaching his father on the phone. John grudgingly admits that he's right. Interrupting, Sam's phone rings and Meg, who they thought dead, demands to speak with John. She informs him that she murdered Jim Murphy and is now with another friend, Caleb. She wants the Colt.

In desperation, John plays dumb and Meg promptly kills Caleb. She says she will keep killing all his friends until he hands over the Colt. Capitulating, John agrees to meet her in Lincoln at midnight for the trade. The boys protest handing the gun over, but John has a plan: they will use a substitute gun since Meg doesn't know what the real one looks like. In an emotional revelation, he admits again that he needs this job to finally be over. When Dean returns with the fake Colt, he pleads with John to not throw his life away, as he's no good to them dead. John tells them to do the same. He hands over the real Colt and the task of killing the demon to the boys, charging them with finishing the job he started.

John arrives in Lincoln to meet Meg. He cases the territory for escape routes and traps and finds a reservoir to bless. While the boys stand watch over Monica and her family, John confronts Meg. She is joined by a demon named Tom. John hands the gun to Meg and she in turn hands it off to Tom, asking if he thinks it's the real thing. Without warning, he shoots Meg. She's pissed but she doesn't die. In shock and anger, Meg rounds on John now that it is obvious the gun isn't the real Colt. He runs and deters them by releasing a valve, spraying them with the Holy Water he prepared earlier. Outside the building, John finds his truck's tires have been slashed. Running, he finds himself trapped in a dead end.

Meanwhile, seeing the house lights flicker and hearing static on the car radio, the boys recognize the signs that the demon is coming and they break into the house in attempt to save Monica and Rosie. Racing to the nursery, Sam faces the demon over Rosie's crib. He hesitates for a second before firing off a shot, but the demon vanishes too fast. Grabbing Monica as Dean saves Rosie, they run from the burning house. Dean stops Sam from trying to reenter the burning building to reach the demon.

Back at the hotel room, while Dean is anxiously trying to contact John, Sam is angry that Dean stopped him from going after the Demon. Dean confronts him about his desire for revenge and self-sacrifice, stating that if it means Sam getting himself killed, he hopes they never find it. Sam's anger boils over and he pushes Dean into an emotional confession. Shocking Sam into the present, his focus shifts back to John. Dean tries his father's phone again, it is answered by Meg and to their horror she promises they will never see their father again...