- Simone, a gorgeous blonde, comes to Smallville hypnotizing Clark with a blue pendant ruining his relationship with Lana, as well as hypnotizing Martha and Lex.
- Two men who collect samples of a deadly virus in a quarantine zone in Sierra de la Botija, Honduras (Central America), are attacked by professor Milton Fine (AKA: the Brainiac). In Smallville, Clark is hypnotized by the beautiful seductress/con artist Simone, who attempts to find out his secret. Simone succeeds, but hides Clark's secret from Lex to take advantage of Clark and hypnotizes Chloe to keep her quiet about her powers. Clark decides to end his relationship with Lana. Meanwhile, Lex travels to Honduras to look for the mysterious Kryptonian spaceship and meet Milton Fine, who wants Lex's help to find and identify a deadly alien threat. At the end, heart-broken Lana visits Lex...—Claudio Carvalho, Rio de Janeiro, Brazil
- An easy-on-the-eyes young woman arrives to town, and with a blue necklace that contains red-K at its center, rocks Clark's world, turning an appalled Lana away from him for possibly the final time. Surprisingly, the woman called Simone was hired by Clark to see if Clark is unusual at all. Meanwhile, Lex is in Honduras trying to discover the whereabouts of Professor Milton Fine and a virus that may be spreading from a jet-black ship that the natives are abuzz about. Finally, when a conflicted Lana goes to Clark to ask what he was doing with Simone, he ends their second relationship by saying "I don't love you."
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