The title is a play on A Fistful of Dollars (1964), a "Spaghetti Western" starring Clint Eastwood. However, the first half of the plot is similar to another Eastwood Spaghetti Western, The Good, the Bad and the Ugly (1966). The plot of "Fistful" had already been sampled in The Black Wolf (1996). The second half resembles any of the Indiana Jones movies.
At 14:07 the skeleton on a wheel is a reuse from a previous episode.