Blade's mother, the Vampire Queen, has come to New York and is hoping to transformer everyone into vampires. To stop her, Blade, Black Cat, and Spider-Man will need Morbius' help.
Miriam, the Vampire Queen and Blade's mother, has arrived in New York to control the human population to be her vampire minions. With no alternatives on stopping the villainous queen, Spider-Man and Felicia decide to rely on Morbius on stopping Miriam's fiendish plot.