Chloe states her mother left when she was 12, but in "Lineage", she told Clark her mother left when she was five. This was later clarified in Smallville: The Visual Guide: her mother left when she was five, but had been institutionalized since she was 12. Though, this was retconned by "Progeny", where Moira is shown to be institutionalized, when Chloe was eight-years-old.
Alfred Gough stated in the DVD commentary for "Thirst" that he felt this was the "most boring episode of the season."
In this episode, Chloe's mother has blonde hair. In all future episodes, she is a brunette.
This episode contains two deleted scenes on the Season Five DVD set. In the first deleted scene, Clark sneaks into the hospital room and undoes Chloe's restraints, saying that he will not allow Chloe to be sent to Belle Reves. Heavily drugged, Chloe tells Clark that he's her hero as he carries her out. In the second deleted scene, Lois explains to a new sheriff (whose actor is uncredited) how she discovered the corpse after pulling the tile off the wall (Clark has already left the apartment to take Chloe to the Kent house). At Lois' insistence, the sheriff tells her the dead girl's identity and that another similar crime scene has been discovered just weeks prior, that Chloe shouldn't be "playing fugitive" and advises her to call his direct number. The sheriff is named "Sheriff Carson" by a fellow officer (credited as "Detective Berg"), and Smallville's producers have not clarified whether this is the successor of the late Sheriff Nancy Adams, who was killed on duty three episodes ago in Lockdown. However, the character himself claims "I'm the sheriff, Miss Lane", and Lois describes to Clark in a later scene that "the new sheriff is a little green". When Lois is later kidnapped, she is just about to make a police call, presumable to the very number that Sheriff Carson gave her.
Kristin Kreuk makes her 100th appearance as Lana Lang in this episode.