Vera Miles and Martin Milner also co-starred in a Twilight Zone episode "Mirror Image". It was after filming the Twilight Zone episode that Milner filmed the pilot for Route 66.
The title comes from the 17 line poem "Gone," by Carl Sandburg that ends with the two lines, "Everybody loved Chick Lorimer./Nobody knows where she's gone."
Two classic river boats are shown, the Goldenrod Showboat and the Admiral. Tod and Ellen go in the Goldenrod Showboat, one of the last showboats to be on the river.