When Doc Baker is informing Caroline that she is not pregnant and that she is actually going through menopause, he mentions the fact that she is going through menopause at a young age and reminds her that she has borne five children. In real life, Caroline Ingalls did give birth to five children - four daughters and one son. Charles and Caroline's only son, their fourth child, Charles Frederick, only lived to be nine months old. Caroline gave birth to her fifth and last child, Grace Pearl, at the age of 37.
This episode marks the last appearances of Alison Arngrim(Nellie Oleson) and Steve Tracy(Percival Dalton)
James Gallery (Ed Poulson) also played Arnie Cupps in Whatever Happened to the Class of '56 in season 6