This episode has many ties to Frankenstein, from the Hulk befriending a child and being attacked by villagers, to an end scene with Sasquatch floating into the Arctic Ocean on an iceberg.
In the comics, Dr. Walter Langkowski was trying to unlock the power of the Hulk with gamma rays. However, the gamma rays did not directly mutate his cells; rather, the gamma energy breached an inter-dimensional barrier, and allowed Langkowski to channel a mystical being called Sasquatch (which explains why he's the only gamma-irradiated being who isn't green). Of course, Langkowski thought that it was due to the gamma for a long time.
Sasquatch appeared as a member of Alpha Flight in the "X-Men: The Animated Series (1992)" episode Repo Man (1993). Both episodes were written by Len Wein.
This is the only appearance in the Marvel Animated Universe of Sasquatch's human form Walter Langkowski.