"One of Our Bottles is Missing" opens with Dr. Bellows once again making an unannounced call on Major Nelson, in the middle of a ping pong match with an invisible Jeannie, this time accompanied by wife Amanda (Emmaline Henry, her second appearance). Mrs. Bellows already demonstrates her flirtatious nature with Tony, intrusively eager to see what a bachelor's home looks like. She admires everything she sees, especially Jeannie's bottle, which she immediately confiscates to have a replica made for herself. Unfortunately, the duplicate is the bottle returned to Major Nelson, while the original, with Jeannie trapped inside, is on its way to the Bellows home, making its very first appearance on the series (represented by the Stephens residence from BEWITCHED). Tony has to retrieve Jeannie before Mrs. Bellows returns home in order to prevent her from discovering the bottle's secret.