House is tinkering on the piano playing "High Hopes" which was the theme of President Kennedy's campaign.
Although House mentions the White House is not called the White House due to the paint job and insinuated that a black president wouldn't come along very soon, three years after the episode aired, Obama, the first black president, took up residence in the White House.
Like President Obama in real life, Senator Wright was also a senator before running for president. Obama was elected in 2004 as a senator from Illinois before running for president and being elected in 2008.