In this episode, Jonathan tells Mark that he will be leaving him to be with his wife. Mark complains that he liked helping people and will miss not working with Jonathan. Jonathan states "You don't need an angel to help people." This is the same line he told Mark in the pilot episode when Mark first suggested they team up to help people.
The movie Heaven Can Wait (1943) is a classic Hollywood film starring the gorgeous Gene Tierney. The cinema was one playing "oldies". Michael Landon was fond of old Hollywood, and even used a few stars in this show, like Lew Ayres and Don Ameche, who also starred in the above referenced film
This is a sequel to the episode Keep Smiling, episode 16, on season 2.
Caz is a returning character. He was the camp leader in the episode All the Colors of the Heart, Season 4, Episode 8.
This is a spiritual successor to the 1972 Bonanza episode, ''Forever.'' In both ''Bonanza'' and ''Highway To Heaven,'' Michael Landon's character loses the love of his life and the future that come with it, becomes disenchanted, and goes on solitary journey of self-discovery.