In this episode, Sam (Ted Danson) recalls that Frasier (Kelsey Grammer) had told him that his dad was a dead research scientist (which had happened in an episode of Cheers (1982) years earlier). This inconsistency is explained by Frasier saying that he and Martin (John Mahoney) had a fight before Frasier made that statement to Sam.
The remarks that Sam makes about Niles looking like Frasier when they first met and not knowing that Frasier had a brother are accurate to the creation of the Niles character. The character of Niles Crane was written and created for the Frasier spin-off. Additionally, David Hyde Pierce was hired because of his physical resemblance to Kelsey Grammer during his early years on Cheers.
Niles (David Hyde Pierce) makes a reference to the heart condition that required surgery in Season 10.
Ted Danson (Sam Malone) and Peri Gilpin (Roz) would go on to play a married couple on several episodes of CSI: Crime Scene Investigation (2000).