This episode is an extended critique of (allegedly) brainless people in American politics. The script mentions a number of Republicans of the early 1990s. Marshall and Simon find a "Bush/Quayle 88" bumper sticker in a homeless man's shopping cart, prompting Marshall to quip, "Well, at least we know he's not a liberal." Later, we hear that Eunice Danforth once negotiated a multi-million-dollar plot orchestrated by Ed Meese to steal the 1980 election "by pumping MacGyver's brain into Ronald Reagan, thereby quadrupling his IQ."
Eunice Danforth's last name is likely a reference to James Danforth (Dan) Quayle, the Vice President of the United States when this episode aired. Quayle is from Indiana.