Plot

Cheyenne scouts for a railroad to lay track to the West. Where the track goes may not be up to the company paying for the route as someone else has a preferred one. At the same time Cheyenne wins a Chinese pearl - a woman.

Cheyenne has been hired to scout a route through Shoshone territory based on his ability as a Cheyenne blood brother. He works with surveyor Ross Andrews, a younger and adventurous fellow. Cheyenne negotiates a pact with Chief Red Knife for a pass through their land with the promise the railroad will bypass their burial grounds and provide medicine and food. The railroad is happy with the agreement but their foreman Tom Fanshaw is not happy nor is freighter John Bishop who based on Fanshaw's advice invested his money with a syndicate in property the railroad is bypassing based on the route Cheyenne obtained from the Shoshone. Fanshaw tries to have Cheyenne killed but fails. His last attempt is based on forcing the Chinese girl Mei Ling Soong Cheyenne won in a rigged raffle to poison him. Cheyenne thought the raffle was for a Chinese pearl which turned out to be the girl. She refuses to leave his side as she adores Cheyenne.—Anonymous

Cheyenne wins a "pearl of great price" named Mei Ling in a phony lottery. He does his best to return her where she belongs but she does her best to stick with him against his better judgment. A corrupt railroad line boss convinces her relative to get her to poison Cheyenne or Mei Ling's father will die. She invites Cheyenne to a picnic lunch. Instead of giving the poison to him, she takes it herself. Now Cheyenne must get her to doctor but there's not much time.