Tish McCarthy is a pseudonym that writer Elizabeth Devine used to sign the story for this episode. When asked why she didn't use Devine, the writer answered: "Primarily because the episode was based on an actual case of mine that had just happened and hadn't been to court yet. Although it was changed for TV, I didn't want to interfere with any aspect of putting away a murderer of a whole family by having my name pop up in a crime scene that might seem familiar. I chose Tish McCarthy because Tish was my nickname when I was a child and McCarthy is a family name."
It was originally titled "The Beast," but it was changed to "If These Walls Could Talk" when it first premiered. In subsequent reruns, it is now titled "Blood Drops."
Grissom quotes lines from Shakespeare's "Macbeth" twice, and each quote is said by Lady Macbeth.
First appearance of Marc Vann as Conrad Ecklie.