Lorne Greene wears a patch on one eye for protection due to corneal abrasion when sand got into his eye and scratched the cornea. The writers wrote the injury into the script.
The title is based on the expression: "Am I not my brother's keeper?"
This show was a reunion of sorts for Wesley Lau (Carl) and Grandon Rhodes (the Doctor) as they had appeared together in several episodes of Perry Mason, Seasons Five through Eight (1961-1965), as Lieutenant Andy Anderson and the sitting district court judge of the day respectively.
Title is likely an allusion to Genesis 4:9, where God tasks Cain on the disposition of his brother Abel. His reply is, "I do not know. Am I my brother's keeper?"