The bandage across Harold's eye moves or disappears throughout the beginning of the movie.
When Harold complains about Kumar using the toilet while he is trying to shower, Kumar reminds him that they just ate 30 burgers and 4 large orders of fries. In the first movie when ordering their food at the White Castle, Harold asked for 30 sliders, 5 french fries, and 4 large Cherry Cokes, while Kumar ordered the same except with Diet Cokes.
While Harold and Kumar are on the flight to Amsterdam, Harold is watching a movie on his laptop. When they show a shot of Kumar he has a pillow behind his head. They change shots and come back to showing Kumar, where the pillow is different, with a dark blue stripe. Finally, the last shot of Kumar in the sequence the pillow is missing.
While Harold and Kumar are talking to Vanessa and Colton, an extra in a blue sweatshirt is seen walking past them four times.
When Harold backs the mustang into the fire hydrant the ensuing geyser of water floods the street, but when it shows the basketball players walking over to the car, the street is barely wet.
At the Guantanamo escape a guy uses a wooden sign propped up against the electric fence he's then killed by an electric shock, this wouldn't happen as the wooden post is an insulating material and he never makes contact with the ground. He wouldn't be electrocuted as he isn't completing a circuit.
In the skydiving scene Kumar "swims" towards Harold. In free fall, you can't swim through the air, flailing your arms and legs just destabilizes yourself. To get two people together, all you have to do is face downwards and towards each other.
Whenever the Homeland Security vehicles are shown, they have flashing orange lights. Federal law enforcement vehicles use red or red and blue flashing lights.
Neil Patrick Harris's car is registered in Virginia, but does not have a Virginia state inspection sticker displayed in the middle of the windshield as required by Virginia law.
Thought it is a cliché in movies, fire hydrants are not only designed to break off when hit, but need to have downward pressure applied to open the valve. So the scene in Birmingham when they backed the car over the fire hydrant and the hydrant gushed water is not realistic.
Big Bob wears an upside down rank insignia, has a style of facial hair not permitted for Army personnel, and takes his baton into the cells (which is forbidden to prevent the exact problems shown in this movie). This is to show that he is an outlaw with no respect for rules and regulations.
The guns in the movie frequently shoot many more bullets than is possible for the make's capacity. Since the movie is meant to be a live-action cartoon, where everything is larger than life, this can be seen as deliberate.
During the 'bottomless party' scene, as their buddy explains the theme of the party you see two girls walking over to a chair and a guy in a green T-shirt, also "bottomless". You can see pretty clearly that the guy is wearing a panty-hose or skin colored 'cock-sock' to cover his genitals. You can see it again about 8 seconds later.
When Raza asks Harold and Kumar to pull down their pants at the party, obvious body doubles are used.
When they are in the guest house of George W. Bush, George plops down on the chair and the joint falls into the ash tray. when if pans back to George u can see in in the ash tray still. But when Kumar spot the joint it is sitting there perfectly resting on the ashtray and not in the center where it fell.
Big Bob doesn't unlock Harold and Kumar's cell. He simply slides the door open.
The aircraft that Harold and Kumar are last seen flying in is a C-130 "Hercules", but the interior is that of a Douglas DC-3 or some other plane, not a C-130.
When all three drive up to the whorehouse the white illuminated sign on the right side of the screen says "Girls, Girls, Grils."
About midway through the movie, before Harold and Kumar spot the the two KKK members in the forest and right after Kumar's fantasy sex scene, when they are walking through the dark forest, you can see something metallic clearly reflecting light in the background in the woods as the camera pans sideways following the two actors. The shiny object looks like it might be a mirror of a car, since it is above the ground.
The State Troopers watching the checkpoint where Harold, Kumar, and Neil Patrick Harris are stopped are wearing Louisiana State Police uniforms, but with Virginia State Police patches.
When all three drive up to the whorehouse the white illuminated sign on the right side of the screen says "Girls, Girls, Grils."