Christina Ricci wore a forty-pound chain during filming. Writer and director Craig Brewer brought various different chains on the set and told Ricci to choose the one that suited her best.
The title of the film derives from the Blind Lemon Jefferson song, recorded in 1927.
Samuel L. Jackson learned to play the guitar for this film while completing production of Snakes on a Plane (2006). This film was the other of two films released the same year in which Jackson starred with the word "snake" in the title.
Christina Ricci revealed in an interview that she wasn't the filmmakers' first choice for the role. She said, "They didn't even want me to audition. But I bleached my hair, auditioned and they still weren't fully convinced. They were worried I wasn't going to be sexual enough, so my agents and publicist just inundated them with sexy images of me." That and her willingness to perform nude in several scenes, something other potential actresses didn't want to do, finally convinced them to cast her.
Producers felt that Christina Ricci being scantly clad and nude in most of the movie were huge selling points to attract an audience (which is ironic since they almost didn't cast her because they initially felt she wasn't sexy enough), so they used images of her almost naked in their marketing campaigns (posters, DVD covers, etc.). But Ricci was upset about that because it focused more on her physical assets than her acting. To this day, she refuses to autograph any memorabilia related to the film.