It was the first Disney animated series to be produced in Japan, and to be influenced by Japanese anime.
Greg Cipes (Chiro) also voices Caleb from W.I.T.C.H. (2004), and Beast Boy from Teen Titans (2003).
Lynne Naylor, character designer for Samurai Jack and Hi Hi Puffy AmiYumi served as the show's Art Director, and her husband Chris Reccardi, writer for Samurai Jack and The Powerpuff Girls was the show's assistant director. Naylor and Reccardi were also known for creating the failed Nickelodeon pilot in 2007, titled the Modifyers.
While it received positive reviews from critics and audiences, and was the most successful of Jetix's Animation Concepts, it was cancelled in 2006 for the exact same reason Teen Titans (2003) was cancelled: Low ratings and poor merchandise sales.
The series was first pitched to Nickelodeon, but they turned it down after 9/11 went down, and Ciro Nieli couldn't do a show about monsters destroying a city. Nieli also pitched it to Cartoon Network, who also passed on the project due to similarities to the Powerpuff Girls.