Sophie Clutts is taken with cramps. Sue becomes abusive to her husband. Slippery Slim. Maud, the mule, is also taken with cramps. Zeke, a farm hand, is sent for the doctors. They arrive hastily and attend their patients. The next day, Sophie and the mule become worse, and Zeke is sent for more medicine. He makes a mistake and gives Sophie the mule's medicine and the mule Sophie's medicine. Then things happen. There is a laugh in every scene.
—Moving Picture World synopsis