Created by the same team that made the first two resident evil games under the direction of resident evil creator Shinji Mikami.
Regina carries an Italian Franchi SPAS-12 Shotgun in the game. The same type of shotgun was also used by the game warden Muldoon in Jurassic Park (1993)
The PlayStation version has sold an estimated 2.4 million copies worldwide.
"The Lost World: Jurassic Park" and "Aliens" served as inspirations for Dino Crisis.
To avoid similarities to the Resident Evil series, creator Shinki Mikami said that this game is a "panic horror" game in contrast to Resident Evil's "survival horror".