In one scene, Mel (the dog) has two dog dishes near the door. Bob picks one up and carries it into the kitchen, but when the shot cuts back to the dog at the door, there are still two dishes on the floor.
When Elizabeth comes home in the beginning of movie, Bob had thrown the towel on top of the coat rack. When she walks in and greets Mel, the dog, the towel is on the floor, in the next shot it is back on top of the coat rack.
When Grace mails off the thank you letter at the Zoo, we see a close-up of the front of the envelope, and in large, capital letters we see R.O.B.I. Towards the end of the movie, when Grace finds her letter on Rob's desk, the letters are NOT capitalized, and MUCH smaller, with no periods: robi.
Grace sends her letter to her heart donor's family in a small (5-1/2 or 6") envelope, but when she pulls the envelope out from under the box on Bob's dresser, it's grown to be a full size (9") envelope.
When Bob and Grace kiss at the bowling alley, their noses switch sides between shots.
When Grace receives her new heart, we hear it begin beating at a rate lower than one hundred beats per minute. Transplanted hearts actually beat around a rate of one hundred beats per minute because it is impossible to attach it to the patient's sinoatrial node, the heart's natural pacemaker.
A year after the heart transplant, when Grace goes to the doctor for her check-up, the nurse forgets to pump up the blood pressure cuff. Then, to add to the mistake, even if she HAD pumped it up, when she's taking it off, she doesn't let the air out.
Parking would not be as easy as shown or the streets that empty in Chicago. Traffic is very heavy especially during the day.
In the bowl scene, Bob has a 66 going into the 10th frame. His high game to date is 67. He throws a gutter on the first ball, but a 3 on the second. Afterwards, in the restaurant, the banner says 68. It should show 69.
When Elizabeth is being rushed into the hospital, it's said that she's 34 years old. Later in the film during bowling, Bob reveals that he's 38, yet he also says that he and Elizabeth started dating when they were in the same high school class. This is possible since it is over a year later, which would have made Elizabeth 35/36, and not all high school classes are divided by grade. It is also possible that Bob was simply rounding up to "25 years" when stating how long it had been since he'd last gone bowling and/or he was not also 13 while attending the 13th birthday party of the girl he mentioned.
On the night that Bob loses his wife Elizabeth, her blood on his shirt remains bright red all night and never turns rust-colored, as real blood would as it dries out.
When Bob takes Grace up on the roof of his building, you can
see that the city lights in the background are a backdrop - a fly is crawling over the windows of the building behind them.
Marty exclaims "You've got it!" before he has picked up the phone that is ringing with news of the heart donor. He only says the words "Haven't you?" into the receiver.
When Bob goes in to argue with the men in suits, one of the men has powdered sugar around his mouth, yet he's eating a bagel with cream cheese.