The muscle chart that Franken is drawing on with the red sharpie in the beginning show the breasts as muscles. That is anatomically incorrect.
At about 34 mins, when Jeffrey supposedly drills into his head, the drill bit visibly retracts into the drill, then returns to its unretracted position when removed.
Elizabeth was blonde and wasn't wearing earrings, but when her head and the other body parts are brought to life as Frankenhooker, she's wearing earrings and a purple wig with no indication of anyone having put them on her.
Jeffrey stabs the pet brain with a scalpel, mumbling to himself to be careful, he doesn't want to give it a lobotomy. Actually, a lobotomy is precisely what he is doing.
At about 37 mins, Jeffrey measures Crystal's thigh and pronounces it a "perfect 18 in diameter," but he's measuring the girth, not the diameter.
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