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Jesse's parents, Nick and Irene, were recurring characters in Season 2, but were dropped from the cast afterwards, except for one appearance in Season 4. This was partly due to John Aprea becoming a regular on the soap opera Another World (1964) from 1989-1992.
Bob Saget and Dave Coulier became friends through the L.A. Comedy circuit. Coulier lived on Saget's couch in his early days as a comedian, similar to struggling comedian Joey Gladstone residing in the basement of Danny Tanner's house.
Mary-Kate Olsen is left-handed and Ashley Olsen is right-handed. That is why, throughout the show, Michelle uses both of her hands to write and eat.
The girl's mother, Danny's wife Pam, was killed by a drunk driver in a car accident, as revealed in one episode.
Bob Saget considered leaving the show after the first season due to his disapproval of the writing and story lines.
Mary-Kate Olsen and Ashley Olsen were chosen for the part of Michelle because they were the only twin babies that didn't cry at the audition.