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In the first season, Jesse's last name was Cochran, but in the second season, it was changed to Katsopolis because of John Stamos' Greek heritage. The reason for the change was addressed within the series in an episode in that the last name "Cochran" was a pseudonym Jesse used to make his name sound more like a rock star.
Bob Saget and Dave Coulier became friends through the L.A. Comedy circuit. Coulier lived on Saget's couch in his early days as a comedian, similar to struggling comedian Joey Gladstone residing in the basement of Danny Tanner's house.
Mary-Kate Olsen is left-handed and Ashley Olsen is right-handed. That is why, throughout the show, Michelle uses both of her hands to write and eat.
The girl's mother, Danny's wife Pam, was killed by a drunk driver in a car accident, as revealed in one episode.
Bob Saget considered leaving the show after the first season due to his disapproval of the writing and story lines.
Mary-Kate Olsen and Ashley Olsen were chosen for the part of Michelle because they were the only twin babies that didn't cry at the audition.