This episode marked a rare time where Columbo (Peter Falk) showed anger towards a suspect (Leonard Nimoy).
Leonard Nimoy's Star Trek (1966) co-star (and wife of that show's creator Gene Roddenberry) Majel Barrett provides the hospital announcer voice. Also, both Nimoy and Barrett voiced Star Trek: The Animated Series (1973).
Additional update: As of October 28, 2023 Nita Talbot (age 93) is the only survivor of the top nine cast members in this episode.
The uniquely shaped Operating Room, with observation windows above, also was used as the Beauty Mark lab in Lovely But Lethal (1973).
Peter Falk and Anne Francis share a birthday, September 16, 3 years apart. Francis was born in Ossining, NY in 1930, and Falk, who grew up in Ossining after having been born in NYC, in 1927.