Filemón traditionally wears a bow-tie in the comic-books and in any of the adaptations, except this movie: Here, he never wear a tie.
Chiflágoras is a reference to comic book character Profesor Bacterio, also a mad inventor leading the main characters to trouble with malfunctioning devices. In the comics, Bacterio is responsible for Mortadelo's baldness due to a faulty hair strengthener he invented; here, Mortadelo references the anecdote, replacing Bacterio with Chiflágoras. The main difference is that Chiflágoras is Filemón's cousin, while in the comics, Bacterio is the staff scientist working in the same secret agency as Mortadelo and Filemón.