The young mayor of the South American village of Tonado is dying of poison. Speed volunteers to drive to Dominic and back to get the antidote, but someone is out to stop him.
A supersonic car built by the Racers is sabotaged and they are framed for its bad performance. Now they must work to foil the saboteurs and save their reputation.
Speed heads to Nairobi for the Trans-African Grand Prix. But en route he is dumped into the jungle and must fend for himself amidst giant spiders and gargantuan gorillas.
Trixie wants Speed to lose a race, so that her friend's brother will win and use the prize money to heal her. Meanwhile, a royal jewel is hidden inside a pineapple - one of many given to the competing racers.
A gang of crooks have captured top-secret plans for a new weapon: a tank with a laser device. When Speed tries to interfere, they decide to test the tank on him.
Speed discovers that a former racing driver Gadge Zoomer has taken to car wrestling (demolition derbies) to support his family, and attempts to get him to leave this destructive sport.
The Junkyard Grand Prix is hosted by a rich baron in honour of his missing daughter. But in fact she appears in the race as an unknowing competitor to Speed.
Exactly a year after the Alpine Race, the Car Acrobat Team challenges Speed Racer to a race to determine the superior driver. But all is not what it seems...