Shot in Uncertain, TX, where the Fly-N-Fish Lodge and Airport seen in early scenes still exists.
Director Larry Buchanan later went on record saying, "Never make a swamp picture. Your film comes back and it's all . . . strange".
A "Curse of the Swamp Creature" mask was one of the last items produced by the famed Don Post Studios before it went out of business in 2012.
The titular creature was created using primitive prosthetic make-up and grayish-green body paint, not the infamous scallop-scaled rubber wetsuit and fish head mask with fangs and painted ping-pong-ball eyes Larry Buchanan later used in Creature of Destruction (1968) and It's Alive! (1969).
The film re-uses Ronald Stein's music from It Conquered the World (1956), Invasion of the Saucer Men (1957) and The Terror (1963).