Although this is the second appearance of Speedy Gonzales (his first outing was in Cat-Tails for Two (1953)), he was re-designed after his debut and this is the first appearance of Speedy as we know him today.
This cartoon is the first time Speedy Gonzales and Sylvester meet.
This short won the Oscar for the Best Animated Short of 1956.
In this short, WB's vendor of choice, Acme, has entered the cheese manufacturing business. But later in the cartoon, it seems to have changed its name to Ajax, another popular WB vendor.