The title plays on the term 'Guided missile' - a generic name which encompasses the modern TLAM (Tomahawk Land Attack Missile).
Wile E. Coyote is shown among saguaro cactus in the opening scene, indicating the setting is the Sonoran desert. He is cooking a tin can inside a hewn out cactus, although cactus itself is considered a delicacy in many cuisines.
Stylized desert yucca plants are also seen here and there throughout the background.
Roadrunner speaks via a sign he holds, while Coyote subtly breaks the fourth wall with sidelong glances, as well as producing his own commentary sign.