The head on Holmes' incredibly quickly-pulled bitter at The Rat and the Raven varies considerably from shot to shot - and the pint seems to be mainly foam, which any self-respecting pub drinker would ask to be topped up.
As Holmes & Watson were tucking into their breakfasts, Watson had his dish and spoon in his hands, then in the next shot, he is seen picking his dish and spoon back up again without having put them down.
Just after the butler tells Watson about the flighty girl's description of a ghost she purports to have seen, the camera angles switch showing Watson reach for his open book on the desk twice.
When Watson pulls the filing cabinet drawer open, he uses the first two fingers of his right hand. When the camera switches showing the plaque on the front of the drawer, all four fingers are curled around the handle.
When Holmes and Watson walk over to stand by the side of the lady's bed, Holmes' left arm was hanging down by his side. After the camera angle switched, his left hand was in the pocket of his coat.
When Holmes was lying on the floor, firing his gun at the drawing on the wall, there are very small, but visible bumps where the squib-like things were positioned to make the 'bullet holes'.
Holmes shoots 7 times from a "six-shooter". There were in fact 8-shot revolvers made.
When Holmes is on the floor firing the gun at the wall there are seven holes when he is done firing. Seven shots are heard. The pistol appears to be a six shot .38 caliber revolver. Since he was conducting an experiment, there was no opportunity to reload.
During the storm a bolt of lightning manages to break a window and travels across the room to strike a suit of armour. Witnessing the window breaking, Holmes runs across the room to grab Sally and move her out of the way of the bolt before it hits the armour. This is not how lightning works.
When Holmes first foreshadows the game of chess he looks through the window and deduces that light will be cast on the floor. However, if you look at the shadows cast on the floor which shows a 5 by 5 lattice pattern this is inconsistent with what could be reflected by the sun from the image seen by the window. The curtains that are hung up would block some of the light that is depicted and more obviously Holmes (himself whom is partially blocking the sun) his shadow is not shown and should be shown on the floor below as he is clearly standing in front of the window when the shot of the floor is being shown. Furthermore, the separating piece in the middle of the window running vertically and horizontally is visible behind Holmes and Watson, but is not silhouetted in the floor image.
Early in the film, between 5 and 10 minutes, when Dr. Watson goes to shut an open window with the wind blowing through, the large fan used by the studio to create the wind effect can clearly be heard.
The land grant / crown grant that was given to the Musgraves by a King Henry, lists King Henry as being King of "Great Britain, France Scotland and Ireland." This is in error, since there have been only "8" King Henry's in England's history, the last being "Henry VIII" in the 16th century. England didn't become part of "Great Britain" until 1707, with the "Act of Union" passed under Queen Anne. This occurred 160 years after Henry VIII's death.
There is also some doubt regarding the use of "France", since France oftentimes either wasn't a united country or existed side-by-side with England, thus making for confusion. The English king in question, would likely have referred not to "France" as part of his kingdom, but to which territories (such as Normandy) he controlled.
@ around 20 minutes when Holmes and Watson are talking to Langford, they engage with him briefly then continue up the stairs. Once they start walking on the flat part, the shadow of a boom arm or some other camera equipment can be briefly seen between the shadows of the bannister pieces.