Although author Johnny Gruelle originally presented Raggedy Ann and Raggedy Andy as sister and brother in his books, they are depicted as sweethearts in this film.
The trio of doctors and the Rag Doll Hospital are believed to have inspired elements from the infamous 1980s Raggedy Ann Broadway musical.
This film and The Raven (1942) hold the distinction of being the only non-"Popeye the Sailor" two-reel shorts from the Fleischer studios.
Animator Charles Thorson intentionally patterned his character designs after those from the Walt Disney short Broken Toys (1935).