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- Six women in a suburb to Philadelphia get a deadly disease and later some Africans that live in North Philadelphia are hit by similar, but nevertheless different symptoms.
- At Ellesmere Ice Station in The Arctic an infection that seems to be a flue turns into raving madness. Frank's daughter's birthday is imminent so he is eager to return home soon.
- Investigating a small town's mysterious deadly epidemic, the NIH team must confine their patients to the community's abandoned hospital.
- In a small factory town, a group of children are affected by a mysterious illness. The team suspects the local factory of toxic waste, but as it is the main employer in the town, encounter some resistance in their investigation.
- Both seals and humans die at Monument Bay in California because of an aggressive infection in the lungs.
- A girl seeks desperately help as the rest of her family is hit by a legendary killer.
- A car with deadly ill people crashes into another car.
- An anonymous tip reveals that a hospital in Baltimore has fatal cases of infection after surgery.
- A young girl collapses while 'acting' and two more from the same 'industry' are already dead.
- Two US congressional reps and a Capital Cop fall deathly ill. Bioterrorism is suspected until a commonality arises that is equally explosive politically.
- A number of sufferers of sudden worsening paralysis that may be linked to 9/11 while several women at a military base are experiencing miscarriages at once.
- At a university in Nebraska 2 football player are hit by a serious neural disease and soon after some club girls fall victims to other symptoms.
- An island resort has an outbreak of a serious respiratory disease that resembles tuberculosis.
- Two boys who are brothers from Virginia and two policemen from Baltimore are all infected with plague.
- The same fatal disease hits soldiers returning from Iraq and old people in nursery homes who hardly ever get out of their beds.
- Marburg, a disease that makes the unlucky bleed to death, brings three men to hospital.
- When people in New York City start turning the color blue, the NIH team is called upon to help cure this outbreak. When searching for the cause, a diner holds an important clue - but what is the ingredient that they all had in common? Only 3 weeks on the job, McCabe is sent to investigate a baby whose parents are thought to have been abusing her. A well-known disease is the answer to the question - brittle bone disease.