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- A bus that House was riding crashes. House claims there's a victim on the bus who is dying, but not from the bus accident. He stops at nothing to figure out who the patient is and what is ailing him/her.
- The team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.
- Cristina and Meredith's surgical skills are put to the ultimate test.
- Seattle Grace Hospital is hit with a crisis like no other in its history.
- House's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.
- House and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.
- Vicious claims leadership of the Red Dragon Syndicate. Julia and Spike plan to run away as before, but Spike still feels the desire for revenge, leading to a final confrontation with Vicious and the Syndicate.
- Izzie's memory problems panic Alex, the team takes care of a John Doe who was hit by a bus, Bailey rethinks her pediatrics fellowship, and the hospital endures losses.
- While searching for Mao Yenrai, an executive of the Red Dragon Syndicate, Spike ends up confronting Vicious, his old enemy.
- House tries radical procedures to save Foreman's life; Foreman's father visits.
- When all of House's efforts to rid himself of Amber fail, he turns to someone unexpected for assistance. Meanwhile, the team is left to fend for itself as they try to save a ballerina's life and career.
- Treating a drug addict patient results in House examining his life, his future and confronting his own personal demons.
- Faye briefly teams up with Julia when she assists her escape from a Red Dragon hit squad, and relays a message to Spike about Julia's whereabouts. Spike and Julia finally reunite.
- A car crash involving students going to their college graduation takes its toll on the residents in the ER, Derek's wedding gift is uniquely suited for Meredith - even if the oversight is not. Meanwhile, Denny's return has Derek and Bailey searching for the cause, and the results will change the outcome of the day.
- Taub treats a patient whose dying husband gets better as she becomes sicker, while the rest of the team deals with a devastating loss.
- Darrien steals a car after getting stabbed and hurries to her friend 13's home for help. Chase brings an ultrasound and helps. House performs surgery on his own leg at home after using experimental drugs.
- Teddy is called away on another case, as Henry is brought in for surgery.
- When a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman's former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.
- Spike witnesses a homicide by a deranged serial killer who then goes after him with a full barrage of weapons.
- A police officer in critical condition has bizarre symptoms, and Dr. Foreman finds himself in an unpleasant situation.
- Stuck with clinic duty, House almost wishes he had the boring patients back after he encounters a young woman with an STD and the need to talk.
- House's Amber hallucination becomes more aggressive as sleep deprivation takes its toll endangering a patient, and Chase's bachelor party ends in the emergency room.
- After a burn victim unexpectedly dies in the midst of a chaotic ER, the Chief and board member Jennings interrogate the residents to find the culprit, as all the Mercy West and Seattle Grace residents defend their actions in an effort to save their jobs.
- Teddy asks Cristina to help with an OR patient.
- 6 y.o. Emily gets a nose bleed and faints. Her dad gets her to the hospital, her mom's a doctor. Wilson has cancer, House is there for him.
- A patient's illness has its roots in the body and mind. Wilson and House try to come to terms with the cancer.
- Follows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- The futuristic misadventures and tragedies of an easygoing bounty hunter and his partners.
- Ed places a fake bounty for her own father, in hopes Jet and Spike will lead her to him. They do, and despite a joyous reunion, her father immediately abandons her to pursue his work. Ed and Ein decide to leave the group.
- A ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.
- House and Cuddy are flying back to the US from an international conference in Singapore. While en route a mysterious disease strikes one passenger and an epidemic unfolds, causing House to diagnose in midair since they have missed the halfway mark by passing the north pole. Back in Princeton, Wilson and House's lackeys have a confusing case of what is ailing a woman who came into the clinic and proceeded to have a seizure.
- 2007–200849m8.9 (11)TV EpisodeAgents Corso and Leo come to Colombia to pick up a criminal. Escobar aka "El Negro" (The Black). But things get out of hand when during the flight a passenger takes over the aircraft.
- House tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
- Foreman hires Chase and Cameron as his new team. An African tyrant becomes Foreman and co.'s patient. They're not happy. House is back as consultant. House meets Wilson's downstairs neighbor.
- An idiosyncratic FBI agent investigates the murder of a young woman in the even more idiosyncratic town of Twin Peaks.
- With the help of the powerful Dragonballs, a team of fighters led by the saiyan warrior Goku defend the planet earth from extraterrestrial enemies.
- The adventures of Earth's martial arts defender, Son Goku, continue with a new family and the revelation of his alien origins. Now Goku and his allies must defend the planet from an onslaught of new extraterrestrial enemies.