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The film follows the life of Miggy (John Lloyd Cruz) and Laida (Sarah Geronimo) after their break-up which occurred after the events of the second film. Miggy is now in a relationship with Belle (Isabelle Daza) while Laida is now a fiercer woman after living in the United States. They try to co-exist in the same company while Laida tries to oppose Miggy's business decisions through a series of events which make them realize the definition of true love.

Furniture supplier Ram (Derek Ramsay) is happily married to Charmaine (Cristine Reyes). One day, Ram lands a big client, a new luxury resort. But he needs the help of Kara (Anne Curtis), the daughter of the owner of the resort, to finalize the deal. Kara's help, however, comes with a price, because she fancies Ram to be her lover. Not before long, Kara successfully seduces Ram, even though she knows about his marriage. When Charmaine learns of the affair, she finds ways to fight for her husband's waning attention.

A gay man tries to prove himself by joining the military.

Bernice and Detty are half-siblings whose bitter rivalry dates back to when they were kids. When their father passed away, things went downhill from there which led to the two siblings never speaking to each other again. That changes when Detty applies to be Bernice's assistant, not knowing that Bernice is her sister.

Apollo wants to redeem himself to Irene, a girl who he leaves on the day of their wedding, but a big problem occurs, Irene has amnesia.

Allan Alvarez (John Lloyd-Cruz) occasionally takes the Pasig River ferry to go to his newly purchased home. On several of these trips, Allan always sees a girl who writes messages on stones and leaves them behind. He picks these stones up and realizes that messages being written are getting worse and worse as time goes by. One day, when the girl writes "Goodbye World", Allan panics and stops the girl from supposedly committing suicide - he soon discovers that this is not the case. He finds out that the girl, Mia Samonte (Bea Alonzo) works as a hotel receptionist in Malaysia. They have exceptional chemistry together, even finding themselves in love after just a week.