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East West 101 is set around the Major Crime Squad in metropolitan Sydney. It is based upon the experiences of actual detectives in a crime unit in Sydney's western suburbs.

Two English children are uprooted from their beloved Liverpool dockside to the alien environment of Australia in the years following World War Two.

Pete & Jerry are cousins living in Sydney's Western Suburbs, where life consists of drinking, getting stoned, getting in fights and hanging out. But things change forever when Pete and Jerry both fall in love with the same girl.