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Multiple teams race around the globe for $1,000,000 to 'amazing' locations.

Four girlfriends, Silvana, Rita, Lucia and Elvira find themselves, for a strange fate, altogether at the end of long relationships. They resolve to take care one another at home, reading, chatting and cooking. Silvana is still in love with Niki, a painter with which were involved heart and soul. In order to eradicate from Silvana's heart the love for Niki, her friends decide to put her through a psycho-magic rite, following the instructions of an Alejandro Jodorowski's book.

Maria Grazia's son is infected by a serious illness that will change their lives.

In an act of kindness, Italian strangers impart a small but significant gift to a lost pair of Racers. An arduous task takes its toll on one Racer who breaks down in tears while rushing through a bustling town. Bad luck plagues one Team who, while hitting traffic, realizes they are driving in circles and wasting valuable time. At the Roadblock, one team member struggles to complete the task as their unsupportive teammate rants from the sidelines.