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- A bus that House was riding crashes. House claims there's a victim on the bus who is dying, but not from the bus accident. He stops at nothing to figure out who the patient is and what is ailing him/her.
- The team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.
- House's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.
- House and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.
- House tries radical procedures to save Foreman's life; Foreman's father visits.
- When all of House's efforts to rid himself of Amber fail, he turns to someone unexpected for assistance. Meanwhile, the team is left to fend for itself as they try to save a ballerina's life and career.
- Treating a drug addict patient results in House examining his life, his future and confronting his own personal demons.
- Taub treats a patient whose dying husband gets better as she becomes sicker, while the rest of the team deals with a devastating loss.
- Darrien steals a car after getting stabbed and hurries to her friend 13's home for help. Chase brings an ultrasound and helps. House performs surgery on his own leg at home after using experimental drugs.
- When a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman's former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.
- "Flying" boys? In fact it refers to the kids with abnormal behavior. Some of them have lost their parents and family, some are abandoned by their family or school. The shattered hearts and souls of those children are like a broken puzzle, now Reverend Huang, youth detention officer Su-Wei Lu and teachers of Faith and Love Youth academy have come up the decision to help the boys to mend and complete the puzzle of their life. The challenge of one thousand kilometer island tour by unicycle? Yes. They believe the only way to transform those kids' life to a positive direction is to help them gain back their self-confident by tasting the flavor of success. The children started to have faith in themselves; they believe that if they insist and never give up, they can surely make it. During the journey they have experienced tiredness in the body and struggle in their mind, however the love and affections of the adults have softened the children's hearts. The project for the 30 boys to go around the island on unicycle has finally come true in the hot summer days.
- A police officer in critical condition has bizarre symptoms, and Dr. Foreman finds himself in an unpleasant situation.
- Stuck with clinic duty, House almost wishes he had the boring patients back after he encounters a young woman with an STD and the need to talk.
- House's Amber hallucination becomes more aggressive as sleep deprivation takes its toll endangering a patient, and Chase's bachelor party ends in the emergency room.
- 6 y.o. Emily gets a nose bleed and faints. Her dad gets her to the hospital, her mom's a doctor. Wilson has cancer, House is there for him.
- A patient's illness has its roots in the body and mind. Wilson and House try to come to terms with the cancer.
- A ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.
- House and Cuddy are flying back to the US from an international conference in Singapore. While en route a mysterious disease strikes one passenger and an epidemic unfolds, causing House to diagnose in midair since they have missed the halfway mark by passing the north pole. Back in Princeton, Wilson and House's lackeys have a confusing case of what is ailing a woman who came into the clinic and proceeded to have a seizure.
- House tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
- Foreman hires Chase and Cameron as his new team. An African tyrant becomes Foreman and co.'s patient. They're not happy. House is back as consultant. House meets Wilson's downstairs neighbor.
- While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- Chaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.
- When the son of a man in a vegetative state starts going into a coma, the vegetative man is reawakened chemically by House, who hopes to get some clues to the son's problems.
- A couple risk their lives getting from Cuba to see House, but his preoccupation with staff issues may cost the woman her life.
- House is forced to choose a new staff... and gathers 40 applicants to start narrowing down the field. Meanwhile, an Air Force pilot wants House to treat her secretly so she doesn't ruin her chances of becoming an astronaut.
- A person takes House, Thirteen and others as hostages. He's seen several doctors but none have found what ails him. As they work towards finding a solution, Thirteen makes decisions which leads her to think about her own condition.
- When an old friend and former patient of Wilson's experiences paralysis in his right arm, Wilson puts himself on the case. House wagers Wilson that the patient's symptoms result from new cancer cells. Wilson accepts even though he is reluctant to believe the cancer has returned. With the help of the team, Wilson works to find a more optimistic diagnosis, but when things take a turn for the worse, and Wilson must address his inability to separate patient from friend. Meanwhile, Cuddy seeks advice in her search for real estate.
- When drug dealer Mickey mysteriously collapses while negotiating a sale, his partner-in-crime, Eddie, accompanies him to Princeton Plainsboro for treatment. But with a major deal pending, Mickey is not forthcoming with the necessary personal information the team needs to treat him. As Mickey's condition worsens, the team resorts to old-fashioned detective work to solve the case. Meanwhile, House and Wilson compete for the affection of a new neighbor, and Chase, Thirteen and Taub attempt to play a practical joke on Foreman.
- House entertains a school class on Career Day telling about his patient, a college student, who coughed up his lung. He spices up the story with quotes from movies. He later gets advice from 2 students outside principal's office.
- House gets parole at his hearing, but he still has to survive 5 more days in a prison filled with violent criminals. One of them wants 20 Vicodin "or else". He helps the prison doctor diagnose a patient.
- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- On Valentine's Day, House meddles in relationships as he works to diagnose a teenager who has a genetic inability to feel pain.
- Down to 10 candidates for his team, House splits them into 2 groups to diagnose a patient whose short lifespan has been made even shorter. Foreman leads his own team to diagnose a patient at his new workplace.
- A victim of a mugging presents with neurological symptoms and begins to mirror the behaviors of his doctors. Foreman joins the new fellows in seeking a diagnosis; Cameron and Chase takes bets on whom House will fire next.