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- The everyday lives, professional and personal, of the doctors, nurses and patients who find themselves, for various reasons, in the wards of the frenetic cardiac unit of Holby City General Hospital.
- Amanda Redman is to star in a new six-part series for ITV1 about a mother trying to keep her family on the straight and narrow. Called Honest, the comedy drama will see Redman play Lindsay Carter, a woman whose husband has spent four years in prison for robbery. On top of this, she has a bunch of wayward children, including a daughter obsessed with becoming the new Naomi Campbell and another who is blackmailing her deputy headmistress so she can bunk off school. The series follows Redman's character as she attempts to keep her family in order.
- Thirty years after the death of a suspected terrorist, the man's daughter receives an anonymous note claiming he was murdered. Clues lead the team to the Greenham Common antinuclear protests of the 1980s.
- In 2010 trainee doctor Lydia Dryden was found dead in her flat after visiting Bar 393 night club. Neighbours reported a possible stalker lurking outside the building but her parents, both surgeons, do not recognize him from the Identikit picture. Married Laurence Devlin, another surgeon, denies having an affair with Lydia though it transpires that he is her actual father, which her mother Monica has kept from husband Hugh. Lydia's sister had a drug habit and Lydia was suspected of stealing from the hospital medicine cabinets to help her. then the stalker is revealed, a man whose wife died during an operation performed by Laurence and Lydia. He denies killing her but helps lead the team to the true murderer.
- Ted Case joins the team to reopen the murder of vicar Leonard Whitechurch, a white man with a black wife who was stabbed in 2006 after receiving racist hate mail. His widow Alicia tells them that his curate Wendy had a crush on him but she hung herself two years after his death. The poison pen letters are traced to ex-convict and white supremacist Kevin Duncan but Ted believes the motive to be more complicated than purely racial. Duncan admits he wrote the letters in revenge as the victim disapproved of his dating his daughter Sally but a revelation from Leonard's younger son Luke exposes a rift in the family and leads to the solution of the murder.
- At Brian's insistence, the UCOS team investigates a bizarre case from ten years before where a hypnotized woman subsequently killed her husband. Although the woman, Katie Briers, was found not guilty, the magician in question, Billy Carse, had his career ruined. Carse is now dead but as Jack examines the script used to hypnotize the woman, he realizes that there were subliminal messages throughout that led her to kill. The question is who planted the messages and why. They focus on Carse's rival, Brandon Skye. Meanwhile, a disbelieving Gerry allows himself to be hypnotized to prove it can't be done, but afterward no one will tell him what happened.
- Ten years earlier the charred corpse of young poet Sean Doherty was found in the scrapyard of Turkish drug-dealer Mehtin Topal, though Topal was not convicted of the killing. Now the case is reopened and the team interviews Sean's contemporaries, including his tutor and lover Sarah Powell and ex-flatmate Luke Oswald, now a media darling. Unlike cynical Gerry, Brian is taken by the world of poetry but Sean's brother-in-law Eoin also claims that Sean had gangster connections. CCTV provides an unexpected clue to the solution of the case, fuelled by Brian's poetical observations and leading to a surprising discovery.
- Gerry is approached by Ralph Paxton, a boyhood friend who became a career criminal and was imprisoned for a jewel robbery. Ralph believes that his grandson, architecture student Jake was murdered by his partner in crime Wayne Pelham because the boy discovered the loot hidden in a tower block due for demolition. After interviewing Jake's brother and his college tutor the team locate Pelham, who informs them that others knew about the hidden jewels. The team eventually end up with two prime suspects, both of whom believing that they were acting out of principle, though one is the killer. Gerry also has to overcome his dislike of the solicitor to whom his daughter Caitlin is getting married.
- In 2008 body-builder Mark Rix died of a heart attack, seemingly caused by a surfeit of steroids. Now a sword is found in his old lock-up, which decapitated an unknown man just before Mark died. Mark was a member of Imperium, a group re-enacting life in Ancient Rome and Steve and Sasha learn from Imperium members Julia Kane and Tim and Tessa Dugdale that he believed himself to be Marcus Rex, incarnation of a gladiator. Forensic scientist Fiona Kennedy identifies the murder victim as a Romanian gangster who sold illegal steroids and the team deduces that Rix used Imperium's foreign dates to import them. After confessing to Fiona that his estranged wife Sarah is in a secure unit, having tried to kill him and his daughter, Danny goes undercover at Imperium, where he recognizes Julia as another undercover cop. Eventually the team learns the truth about both men's deaths from Julia before Danny goes on a date with Fiona.
- In 2002 married Anna and Jim Briggs - who worked for a look-alike agency - were found dead in a supposed suicide pact. Now Anna's phone has been discovered, containing amorous texts to a mysterious lover. The team interviews other look alikes, including Anna's sister and professional rival, Lesley, and ex-soccer star Mikey Bishop, whom Jim impersonated and who says that he met Jim and found him harmless. They also find Mikey's wife Clara is over-protective of her husband as it becomes apparent that he was Anna's lover. a truly bizarre role reversal however proves the key to solving the murders of the two victims.
- The team get involved when graffiti claiming 'I Killed Flak' appears around London, Flak being tag artist Danny Tyler, killed four years earlier. He was part of an artist collective the Maze Group which broke up when Danny received patronage to go solo from art lover Sir David Bryant, a fact which caused resentment from others in the group. Gallery owner Sara Hamlyn admits responsibility for the current graffiti, a publicity stunt for her Flak exhibition but draws the team's attention to a theft from her gallery of one of Flak's works before he died. The team are led to believe that Sir David stole it as he needed money and killed Flak during the resultant argument. Another ex-Maze group member Kevin Humphreys has been blackmailing Sir David as a result. But then Bryant's wife Catherine gives Sandra information which puts things in a different light. Brian has all the while been enjoying a following on Twitter as Top Cop 99, a fact which almost puts the case in jeopardy.
- Would-be Euro MP Fintan MacEntee, a former member of the Irish Republican Front, approaches Sandra regarding Barbara, teen-aged daughter of a wealthy arms manufacturer Kenneth Linden-Warner, who was kidnapped in 1983 and, though the ransom was paid, was never seen again. At the time the Front admitted responsibility but MacEntee now claims that it was purely a publicity move and the Front never took Barbara. Sandra's belief that it was an inside job is confirmed when it is discovered that Barbara's brother Michael, who did not get on with his father, shared a squat with MacEntee and helped him prepare the ransom note to get money from his father. Barbara had also rowed with boy-friend Greg Hampton, now married to Barbara's supposed rival but in fact anything but. The family did indeed have secrets and Miss Jones, Linden-Warner's loyal former secretary, knows all of them as well as the actual fate of Barbara.
- A birdwatcher is discovered murdered in the Saint-Marie jungle.
- Illegal Turkish immigrant Asye Ersoy was working as a barmaid in 2010 but disappeared following a fire which killed the pub's landlord Richard Gibson. Now she has been traced but denies committing any crime. The pub's former pianist Jason claims that Richard was happily married to wife Joanne and she endorses this. Relations with his brother Gavin, a slot machine vendor who wanted to buy the ailing pub, were less harmonious whilst Joanne believes Richard was having an affair with Asye but did nothing about it. The identity of Asye's actual lover and a scam involving the sale of cheap wine, dressed up to appear as of better vintage, are both uncovered before the real killer is unmasked though Gerry and Steve regard the case as a welcome diversion from Sasha's attempts to enter them in a five a side contest.
- Elderly dementia sufferer Nancy leaves her care home to report that her policeman husband Jimmy, who disappeared in 1956 was actually murdered. Harry Page, an old friend of the couple, reports that Jimmy had gambling debts and got into a fight the night that he died. Sasha takes Nancy back to her old house where she recalls Jimmy's violence and jealousy. A grim secret is discovered in the bedroom wall, in turn leading to the solution of the murder. Meanwhile Steve is called to the police station when his son Stewie is cautioned for minor drug possession, which brings him into conflict with his ex-wife Tricia. They do not part on good terms.
- When the recently deceased pathologist Dr Hatton's findings are discredited the team looks into the 2005 drowning in his bath of cricketer AJ Da Silva, a suicide according to Hatton though AJ's father and brother are convinced he was murdered. Ted learns from coach Keith Ainsworth and former captain Ryan Reed that AJ was thoroughly disliked by the other cricketers in his side as an arrogant, drunken womaniser. In fact his affair with a team mate's wife was held responsible for the man's suicide. After another person is found dead the key to AJ's demise is found to be match-fixing and its consequences and, the case solved, Ted springs a surprise on his colleagues.
- The trial of Ricky Hanson starts, and the members of UCOS are scheduled to appear as witnesses. Hanson is the man who killed Jack Halford's wife, but he's on trial for attempting to murder Jack, who was recovering from a car accident over a year ago. Hanson's barrister is clearly out to discredit each of them individually. While at the courthouse, they are asked by an acquaintance of Jack's, Sam Tallis, to look into the death of Ralph Wheeler, who was killed and left his fortune to a tart named Carrie Soper. As they look into the case, they find several possible suspects, including a solicitor, a doctor, and someone with a lengthy criminal record. In the end, the case revolves around a car accident and organ donation.
- With Jack Halford away following the acquittal of Ricky Hanson, Sandra, Gerry and Brian investigate the death of actor Michael Austin, who was shot dead during the performance of a play. The gun was loaded with blanks, but a piece of metal lodged in the barrel killed him. The death was ruled accidental at the time, but Austin's daughter Catherine has recently written a book, and new evidence in the form of a threatening note has come to light. The team is joined by a young officer on the fast track for promotion, James Strickland, the DAC's nephew. They interview Austin's then wife, Helen Brownlow (she's also an actress and the one who fired the gun on stage) and the stage manager, Derek Bennett, as well as Catherine Austin's agent, Mel Simons, who sent the note to her publishers. Forensics indicate that the letter may have been doctored. Meanwhile, the boys have forgotten Sandra's birthday, but she does accept a dinner invitation from the young Strickland.
- Jack attends the funeral of ex-cop Derek Brooker who went to his grave trying to prove that journalist Peter Edelmann was killed by the American Air Force to stop him exposing an alleged U.F.O. crash, and persuades Sandra to re-open the case. The former Air Base Colonel denies that Peter was ever there, claiming he committed suicide, but local ufologists say that they were present with him and a code, encrypted in a lottery ticket, unlocks his findings. It was a plane crash, the corpses all suspected terrorists illegally abducted by the American government. However the ufologists and another eye-witness, an ex-airman whose café has been set alight by persons unknown, are too frightened to testify and the case remains officially unsolved.
- Ex-actress Gloria Gransford draws the team's attention to a clip, posted on the Internet, from a film she made in 1990 called 'Shadow Show', after which the producer Max Stone was stabbed to death and leading lady Eva Roderick disappeared. Director Don Maddox, Gloria's ex-husband, is egotistical and evasive, and the only other surviving crew member from the film - who posted the clip - is found dead. His young boyfriend goes on the run and located Eva, who now has a new identity. A siege situation develops, which Brian defuses.
- Eight years previously clothes designer Ritchie Levene was murdered, stabbed in the neck with a pair of his scissors. For years his ex-wife Sarah has wanted the case reopened and sees her chance when Gerry comes to her for a change in his sartorial image.She suspects Ritchie's younger brother Adrian who assumed control of the fashion company and took it to new heights. Sandra discovers that married Adrian is having an affair with Ritchie's second wife Alison, though they claim it only began some time after Ritchie's death. Then there is Melanie, the nervous P.A. who found Ritchie's body, and Colin Beck, a financier who encouraged Ritchie to invest money in his scheme and also had a motive...
- The UCOS team are drawn into a world of immigration, Albanian gangs and family feuds when they reinvestigate the death of an unidentified man.
- Still missing Jack, the team reopens the disappearance five years earlier of PE teacher Jason Bowe when human remains are found at Peregrine Manor school, where he taught. Of the staff only support worker Helen Hanley is helpful. Stuffy Latin teacher Archie Millgrow argued with Jason about his over-familiarity with pupils whilst former student Eleanor, now the school secretary, and sports jock Oliver believed Jason was having an affair with pupil Melissa. Brian is more concerned that, despite falling intake numbers, school finances are surprisingly healthy and suspects Jason stumbled upon a plot by which wealthy donors subsidised the school in return for favours from old boy Geoffrey Parks, MP, Melissa's father. Then one of the suspects makes a confession but the team is not convinced and believes they are covering for someone else.
- After an amateur sleuth is murdered, a photo of Danny is found at the scene. It turns out Danny was her friend, and he vows to find the killer. Clues lead to a 25-year-old murder and a trip to the countryside.
- In 1989 32-year old Charlie Hayes, a stock market trader, fell to his death, a presumed suicide, from his office building near Tower Bridge but a blow up photograph in a retrospective art exhibition reveals a background figure who pushed him.Cash-strapped Steve takes advantage of insider information as the team interviews Charlie's former girlfriend and colleagues, prime suspect being obnoxious Kevin Dodds, whom Charlie exposed as a rapist and the team brings him in. However the rape gives him an alibi for the murder and Danny and Steve discover that Charlie was sacrificed to prevent him disclosing certain anomalies within the company's trading.