Samuel Gompers wurde am 27 Januar 1850 in London, England, UK geboren. Er war mit Gertrude Annersly Gleaves Neuscheler und Sophia Julian verheiratet. Er starb am 13 Dezember 1924 in San Antonio, Texas, USA.
In December 1924, he was attending a meeting of the Pan-American Federation of Labor in Mexico City. With his health deteriorating, he expressed his wish to die on American soil. He was taken by special train to Texas and died in San Antonio.