- She became a Republican in 1975.
- She earned a bachelor's degree from Duke University in 1958, a master's degree from Harvard University in 1960, and a J.D. degree from Harvard Law School in 1965.
- She was U.S. Secretary of Transportation from 1983 to 1987 and U.S. Secretary of Labor from 1989 to 1990.
- She was president of the American Red Cross from 1991 to 2000.
- U.S. Senator from North Carolina (January 3, 2003 - January 3, 2009).
- As the Secretary of Labor, her office doubled for the FBI director's office in The Silence of the Lambs (1991).
- Apart from serving as Senator and two Cabinet positions (Secretary of Labor and Secretary of Transportation), being married to Bob Dole (from 1975 till his death in 2021), she was in running for Second Lady (in 1976) and for First Lady (in 1996). She is the only woman in United States history with these distinctions.
- Stepmother of Robin Dole (b. 1954).
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