- The only mob boss ever to die in the Electric Chair, he was convicted of the murder of a trucking firm operator on the testimony of Abe Reles, a gunmen for Murder, Inc., who cut a deal the Brooklyn District Attorney. On 12 November 1941, before he could testify against mob boss Albert Anastasia, Reles, while in police custody, "fell" from the 6th-story window of his hotel.
- "Lepke" is Yiddish for "Little Louis"
- Head of Murder, Inc., the national crime syndicate's enforcement arm. As many as 100 deaths were attributed to Lepke himself, while those under his control may have slain 1,000.
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