Annie Glenn nació el 17 de febrero de 1920 en Columbus, Ohio, Estados Unidos. Estuvo casada con John Glenn. Murió el 19 de mayo de 2020 en Minnesota, Estados Unidos.
She met John Glenn when they were children growing up in New Concord, Ohio. They went to high school and Muskingum College together and were married in 1943, when he was a Marine Corps pilot.