- Was almost traded during the 1999 season. He ended up helping the Yankees to the World Series that year.
- Has the most consistent pickoff move in the MLB.
- The only MLB pitcher since 1930 to win at least 12 games in each of his first nine seasons.
- Children: Luke Jackson (19 June 2005), Joshua Blake (3 November 1994), Jared (28 May 1998), Lexy Grace (10 January 2001).
- Drafted by the New York Yankees in the 22nd round of the June 1990 free agent draft; signed 25 May 1991.
- Pitcher with the New York Yankees (1995-2004, 2007) and the Houston Astros (2004-2006).
- Made major league debut on 29 April 1995.
- Named to Baseball Digest magazine's 1995 Rookie All-Star Team.
- During game five of the 1996 World Series, in the bottom of the 6th inning, John Smoltz was on second base for the tying run. A batter made an attempting sacrifice bunt, Andy Pettitte grabbed the ball with his bare hands and threw John Smoltz out at third base to make it one out. After that, Pettitte made a double play. That was an important play to help the Yankees win 1-0. The Yankees won the World Series in game 6.
- Friend and former teammate of Roger Clemens.
- Announced his retirement [February 4, 2011].
- (December 3) Pettitte's agent announces that Pettitte has decided to play for the New York Yankees in 2008. (2007)
- (11 December) Signs a 3-year, $31.5 million free agent deal with the Houston Astros. He will earn $5.5 million in 2004, $8.5 million in 2005 and $17.5 million in 2006, with $7.5 million defered until 2008. (December 2003)
- Returned from retirement to play for the New York Yankees in the 2012 season.
- Pitched his final career game against the Houston Astros with a complete game on September 28, 2013. The Yankees won that game 2-1.
- The Yankees announced that they will be retiring his number 46 on August 23, 2015.
- New York Yankees All-Time Games Started Leader (438) (tied with Whitey Ford).
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