Tommy DeSimone nació el 24 de mayo de 1950 en Cambridge, Massachusetts, Estados Unidos. Estuvo casado con Angela. Murió el 14 de enero de 1979 en Nueva York, Nueva York, EE.UU..
Although several Mafia sources have stated that DeSmone was murdered in early 1980 because he killed a Mafia boss without permission, and his wife reported him missing early in March of that year, his body was never found. He was declared legally dead in 1990.